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For instance, microglia are nor-mally inconspicuous in the young brain, but with aging,microglia may show signs of activation (Jurgens andJohnson, 2012), even in older persons with normal cog-nition.

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Recently, in a study assess-ing the effect of intravenous sildena?l in neo-nates with persistent pulmonary hypertension, ithas been reported that intravenous sildena? l waswell tolerated and induced acute and sustainedimprovements in oxygenation at the higher dosestudied.

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